LRRK2: dropping (kinase) inhibitions and seeking an (immune) response
نویسندگان
چکیده
منابع مشابه
Lrrk2 Kinase Inhibition
Unc-51 Like Kinase 1 (ULK1) is a critical regulator of the biogenesis of autophagosomes, the central component of the catabolic macroautophagy pathway. Regulation of ULK1 activity is dependent upon several phosphorylation events acting to repress or activate the enzymatic function of this protein. Phosphorylation of Ser758 ULK1 has been linked to repression of autophagosome biogenesis and was t...
متن کاملLeucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response
BACKGROUND Mutations in LRRK2 are related to certain forms of Parkinson's disease and, possibly, to the pathogenesis of Crohn's disease. In both these diseases inflammatory processes participate in the pathogenic process. LRRK2 is expressed in lymphoid cells and, interestingly, Lrrk2 (-/-) mice were reported to develop more severe experimental colitis than their wild type (WT) controls. Here, w...
متن کاملLRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain. GTPases often regulate kinases within signal transduction cascades, where GTPases act as molecular switches cycling between a GTP bound "on" state and a GDP bound "off" state. It has been proposed that LRRK2 kinase activity may be increase...
متن کاملLRRK2 kinase activity modulates presynaptic vesicle release
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson ́s disease (PD). Little is known about its involvement in the pathogenesis of PD mainly due to the lack of knowledge about the physiological role of LRRK2. Our previous results suggest that LRRK2 acts as a scaffold within the presynaptic bouton and that it is involved in neurotransmitter rel...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2014
ISSN: 0022-3042
DOI: 10.1111/jnc.12691